Nucala (Mepolizumab)


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Nucala (Mepolizumab)

Generic Name: mepolizumab

What is Nucala?

Nucala is a prescription medicine used with other asthma medicines for the maintenance treatment of asthma in people aged 12 years and older whose asthma is not controlled with their current asthma medicines.

Nucala helps prevent severe asthma attacks (exacerbations). It works by reducing blood eosinophils. Eosinophils are a type of white blood cells that may contribute to your asthma.

  • Nucala is not used to treat other problems caused by eosinophils.
  • Nucala is not used to treat sudden breathing problems.

It is not known if this medicine is safe and effective in children under 12 years of age.

Who should not use Nucala?

Do not use Nucala if you are allergic to mepolizumab or any of the other ingredients. See the end of this page for the complete list of ingredients.

Before receiving


Before receiving Nucala, tell your healthcare provider about all of your medical conditions, including if you:

  • have a parasitic (helminth) infection
  • have not had chickenpox (varicella) or the chickenpox vaccine
  • are taking oral or inhaled corticosteroid medicines. Do not stop taking your corticosteroid medicines unless instructed by your healthcare provider. This may cause other symptoms that were controlled by the corticosteroid medicine to come back.
  • are pregnant or plan to become pregnant. It is not known if Nucala may harm your unborn baby.
    • Pregnancy Registry. There is a pregnancy registry for women who receive Nucala while pregnant. The purpose of the registry is to collect information about the health of you and your baby.
  • are breastfeeding or plan to breastfeed. You and your healthcare provider should decide if you will use Nucala and breastfeed. You should not do both without talking with your healthcare provider first.
  • Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
  • Do not stop taking your other asthma medicines unless instructed to do so by your healthcare provider.

How will I receive Nucala?

A healthcare provider will inject Nucala under your skin (subcutaneously) one time every four weeks.

Mepolizumab side effects

Nucala can cause serious side effects, including:

  • allergic (hypersensitivity) reactions. Serious allergic reactions can happen after you receive the injection. Allergic reactions can sometimes happen hours or days after you get a dose of Nucala. Tell your healthcare provider or get emergency help right away if you have any of the following symptoms of an allergic reaction:
    • swelling of your face, mouth, and tongue
    • breathing problems
    • fainting, dizziness, feeling lightheaded (low blood pressure)
    • rash
    • hives
  • Herpes zoster infections that can cause shingles have happened in people who received Nucala.

The most common side effects include: headache, injection site reactions (pain, redness, swelling, itching, or a burning feeling at the injection site), back pain, and weakness (fatigue).

These are not all the possible side effects of Nucala. Call your doctor for medical advice about side effects.

General information about the safe and effective use of Nucala.

Medicines are sometimes prescribed for purposes other than those listed in a Patient Information Leaflet. You can ask your pharmacist or healthcare provider for information that is written for health professionals.


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